Low risk, high reward
Isolation exercises put minimal stress on your spine and joints and are easy to bail out of, so failure is safe. That makes them the right place to chase the extra stimulus that training close to failure provides.
Yes, taking isolation accessories close to or at failure is safe and effective, unlike heavy compounds.
Accessories, meaning smaller isolation moves like curls, lateral raises, leg curls, and pushdowns, are where training to or near failure makes the most sense. They carry low injury risk and little systemic fatigue, so pushing the last set to failure adds stimulus without wrecking recovery. Save the true grinders for these single-joint movements and keep your heavy compounds like squats and deadlifts 1 to 3 reps shy of failure.
Isolation exercises put minimal stress on your spine and joints and are easy to bail out of, so failure is safe. That makes them the right place to chase the extra stimulus that training close to failure provides.
Going to failure on every set of every accessory builds fatigue that hurts your next sessions. Take the last set or two of each accessory to failure, and keep earlier sets around 1 to 2 reps in reserve.
Failure on heavy squats, deadlifts, and barbell presses is fatiguing and risky as form breaks down. Leave 1 to 3 reps in the tank on those and reserve your all-out efforts for the accessories.
Yes, taking isolation accessories close to or at failure is safe and effective, unlike heavy compounds.