A once a week bro split is not ideal for naturals because it undertrains each muscle across the week on frequency.
The quick answer
For a natural lifter, hitting each muscle twice a week generally builds more than the classic bro split that trains each muscle hard only once every seven days. Muscle protein synthesis after a session stays elevated for roughly 24 to 48 hours, so a second weekly hit captures more growth. Bro splits can still work if total weekly volume is high, but push pull legs or upper lower usually gives naturals a better frequency for the same effort.
How to think about it
Frequency favors two times
The elevated growth window after training a muscle lasts about a day or two, then fades. Training a muscle once a week leaves several days where it is no longer growing, whereas twice weekly restarts that window and tends to add slightly more muscle over time for naturals.
When a bro split is fine
If you can only commit to five days and you genuinely accumulate 10 to 20 hard sets per muscle in that one session, a bro split still drives growth. Enhanced lifters recover faster and lean on it more, but naturals leave a little on the table.
Better default splits
Upper lower run four days or push pull legs run over five or six days both hit each muscle twice while keeping per session volume manageable. That usually beats cramming 20 sets of chest into a single Monday.
Do this
Count weekly frequencyAim to train each muscle twice a week rather than once for better natural growth.
Try upper lowerSwap to a four day upper lower split to double frequency with the same gym days.
Keep total volume equalIf you stay on a bro split, make sure each muscle still gets 10 to 20 hard sets weekly.
Watch session fatigueDo not stack so many sets in one day that the last ones are junk from fatigue.